Recently, a research team at the Comprehensive Cancer Center at the University of California, Davis in the United States identified a key epitope on the CD95 receptor that can cause cell death. Industry analysts believe that this new ability to trigger programmed cell death may open a new door for improving cancer treatment.
The CD95 receptor, also known as Fas, is a type of death receptor. These protein receptors are located on the cell membrane, and when activated, they release signals that cause cell self destruction. Regulating Fas may also extend the benefits of chimeric antigen receptor T cell immunotherapy to solid tumors such as ovarian cancer.
Researchers have identified the most critical epitopes for cytotoxic Fas signaling and CAR-T anti-tumor function. This may provide a therapeutic pathway targeting Fas in tumors.
Research has shown that when death receptors are located, they trigger programmed cell death in tumor cells. Therefore, they provide another more effective way to kill tumor cells and lay a solid foundation for more effective immunotherapy.
Cancer, also known as malignant tumors, is feared due to its extremely short survival cycle, relatively clear death nodes, and unbearable pain and suffering. And high levels of fear can lead to problems with various functions of the human body, especially the immune system, thereby reducing the body's disease resistance and further exacerbating the deterioration of the condition. Further deterioration of the condition will exacerbate the fear mentality, forming a vicious cycle.
Therefore, since the discovery of cancer, humans have been continuously committed to studying its mechanisms, hoping to find the ultimate code and therapeutic weapon for cracking cancer.
The reason why cancer is still difficult to fully "overcome" is closely related to various factors.
Firstly, the metastasis of cancer cells is closely related to the "tumor microenvironment". When cancer cells metastasize, it can be even more difficult to cure, and some people even experience metastasis after discovering the tumor, thus losing the best treatment opportunity.
Some cancer cells, on the other hand, metastasize through the bloodstream or lymphatic system. They must first dissect the tumor, then enter the bloodstream or lymphatic system, and finally reach other locations. At this point, cancer cells will resist the defense forces of the human body and even cleverly evade the pursuit of immune cells, ultimately achieving safe transfer.
However, at this time, they will cause strong attacks on the human body and even directly affect the function of various organs.
Cancer recurrence and metastasis are related to multiple factors, such as drug resistance, which is one of the key factors. Cancer cells can be resistant to drugs through different mechanisms, such as primary resistance and acquired resistance.
After understanding the causes of cancer and the mechanisms of cancer metastasis, and with the unremitting efforts of researchers, in recent years, especially this year, news of breakthrough progress in the treatment of malignant tumors has been constantly spreading.
The Times website reported on October 22nd that scientists have achieved the biggest breakthrough in the treatment of cervical cancer in 20 years. And just in the UK, this research result will save hundreds of women's lives every year.
Recently, a team including the Biomedical Engineering Research Institute of the Chinese Academy of Medical Sciences has developed a new type of human serum albumin drug delivery system, which significantly improves the drug loading rate and achieves active targeted delivery of anti-tumor drugs and efficient photothermal therapy of tumors.
At present, the research results have been published in the internationally authoritative academic journal Nature Communications.
At present, medical technology is still constantly developing and advancing, and significant breakthroughs are being made in the treatment of cancer. Although humans have not yet fully conquered cancer, through active prevention and constantly cracking the cancer treatment password, we believe that in the near future, cancer will definitely be completely subdued.
Therefore, don't be intimidated by cancer, don't care about the timing, believe in science, actively cooperate with treatment, and pay attention to physical fitness. As for the pain caused by cancer, modern medicine also has many treatment methods to alleviate it, and there is no need to be too anxious about it, let alone be dominated by negative emotions. Instead, it is necessary to use good lifestyle habits, Iranian psychology, regular examinations, scientific exercise, reasonable diet, and timely treatment to overcome the disease.
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